![]() HULIQ | National Margarita Day: Recipes to Celebrate With! myGLOSS It's National Margarita Day! Who knew? But now that you do know, we've got some recipes to help you celebrate the holiday with classic recipes and some tasty variations too. First, a good margarita has to have good chips and salsa to go with…so pick up ... It's National Margarita DayMyFox Chicago Today is National Margarita DayCorpus Christi Caller Times It's National Margarita Day - do you have a favorite NJ Mexican restaurant?NJ.com Huffington Post -Long Island Press -San Antonio Express all 42 news articles » |
Wednesday, February 23, 2011
National Margarita Day: Recipes to Celebrate With! - myGLOSS
Friday, February 18, 2011
Scientists steer car with the power of thought
Wednesday, February 02, 2011
Scientists customize a magnet's performance by strategically replacing key atoms
Tuesday, January 18, 2011
Researchers aim to resurrect mammoth in five years
Wednesday, December 22, 2010
Learning to move machines with the mind
Source: Trends in Neurosciences, In Press, Corrected Proof, Available online 20 December 2010
Andrea M., Green , John F., Kalaska
Brain–computer interfaces (BCIs) extract signals from neural activity to control remote devices ranging from computer cursors to limb-like robots. They show great potential to help patients with severe motor deficits perform everyday tasks without the constant assistance of caregivers. Understanding the neural mechanisms by which subjects use BCI systems could lead to improved designs and provide unique insights into normal motor control and skill acquisition. However, reports vary considerably about how much training is required to use a BCI system, the degree to which performance improves with practice and the underlying neural mechanisms. This review examines these diverse findings, their..."
Friday, December 17, 2010
HDB's first eco-precinct
Thursday, December 16, 2010
Doctors may have found HIV cure
Tuesday, December 14, 2010
Ageing study to be done in 3 phases
Ageing study to be done in 3 phases: "SINGAPORE : The five-year study in Marine Parade on ageing, announced by Senior Minister Goh Chok Tong on Sunday, will be carried out in three phases."
Thursday, December 09, 2010
Singapore's salad days are over
Perhaps one should not blame a country, but bite down and realize that to produce something, one needs to work hard...
But at the same time, the need for and nature of freedom in research is poorly understood in most government and industrial organization, in my opinion.
Singapore's salad days are over
Singapore's salad days are over
Nature 468, 7325 (2010). doi:10.1038/468731a
Uncertainty has replaced confidence as economic reality bites science in the city-state and scientists find that their research funds now come with strings attached.
Monday, August 02, 2010
Goodbye Champaign, IL.
It is difficult to say goodbye to you. It means I cannot see you as often as I like. It means that our paths will go separate ways. It means that all the things we've experienced together in the past will be faint memories and I cannot touch them.
This has been and always will be my home. For here is where I have left a part of my heart. That part will very soon split into a hundred pieces, and each go their own way to various parts of the earth. Is this not the most painful thing in the world?
Till we meet again.
Saturday, July 31, 2010
Neuroscience: Movement decoded
Neuroscience: Movement decoded
Nature 466, 534 (2010). doi:10.1038/466534f
J. Neurosci.30, 9659–9669 (2010) 10.1523/JNEUROSCI.5443-09.2010Brain signals in monkeys have been decoded and used to reconstruct three-dimensional arm movements, raising the possibility of future neuroprosthetic devices that people who are paralysed could use to control robotic arms for
Monday, April 26, 2010
Brain-like computing on an organic molecular layer
This is really really cool technology.
Wednesday, April 21, 2010
Reasoning about social conflicts improves into old age [Psychological_And_Cognitive_Sciences-BS]
Aging and wisdom PNAS article just out.
No gain from brain training
The study, a collaboration between British researchers and the BBC Lab UK web site, recruited viewers of the BBC science program "Bang Goes the Theory" to practice a series of online tasks for a minimum of ten minutes a day, three times a week, for six weeks. [More]"
Wednesday, April 07, 2010
Neural mechanisms of ageing and cognitive decline
Neural mechanisms of ageing and cognitive decline
Nature 464, 529 (2010). doi:10.1038/nature08983
Authors: Nicholas A. Bishop, Tao Lu & Bruce A. Yankner
During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest health threats of old age, with nearly 50% of adults over the age of 85 afflicted ...Friday, March 12, 2010
Two views of brain function
Publication year: 2010
Source: Trends in Cognitive Sciences, In Press, Corrected Proof, Available online 4 March 2010
Marcus E., Raichle
Traditionally studies of brain function have focused on task-evoked responses. By their very nature, such experiments tacitly encourage a reflexive view of brain function. Although such an approach has been remarkably productive, it ignores the alternative possibility that brain functions are mainly intrinsic, involving information processing for interpreting, responding to and predicting environmental demands. Here I argue that the latter view best captures the essence of brain function, a position that accords well with the allocation of the brain's energy resources. Recognizing the importance of intrinsic activity will require integrating knowledge from cognitive and systems neuroscience with cellular and molecular..."
A New Spin on Conductivity: Electric Signals Can Propagate through an Insulator
A New Spin on Conductivity: Electric Signals Can Propagate through an Insulator:
An electric insulator, in the simplest terms, blocks the flow of electric current. So it would be a bit counterintuitive, to say the least, if a current on one side of an insulator could produce voltage on the other. [More]
Friday, March 05, 2010
Reduced Neural Selectivity Increases fMRI Adaptation with Age during Face Discrimination
[Link to article if you have journal access]
[Link to Pubmed abstract access]
By Joshua O., Goh , Atsunobu, Suzuki , Denise C., Park
Beckman Institute, University of Illinois, Urbana-Champaign, IL, USA; Center for Vital Longevity, University of Texas, Dallas, TX, USA.
Ventral-visual activity in older adults has been characterized by dedifferentiation, or reduced distinctiveness, of responses to different categories of visual stimuli such as faces and houses, that typically elicit highly specialized responses in the fusiform and parahippocampal brain regions respectively in young adults (Park et al., 2004). In the present study, we demonstrate that age-related neural dedifferentiation applies to within-category stimuli (different types of faces) as well, such that older adults process less distinctive representations for individual faces than young adults. We performed a functional magnetic resonance imaging adaptation experiment while young and older participants made same-different judgments to serially presented face-pairs that were Identical, Moderate in similarity through morphing, or Different. As expected, older adults showed adaptation in the fusiform face area (FFA), during the Identical as well as the Moderate conditions relative to the Different condition. Young adults showed adaptation during the Identical condition, but minimal adaptation to the Moderate condition. These results indicate that older adults' FFA treated the morphed faces as Identical faces, reflecting decreased fidelity of neural representation of faces with age.
NeuroImage, In Press, Accepted Manuscript, Available online 6 February 2010
Sunday, February 28, 2010
Origami and the Brain

For example, some rules may be related to the fact that our neurons have many short range local connections with neighboring neurons, as well as, some long range connections to more distant groups of neurons. Establishing and pruning these connections is dependent on time and stimulation from external as well as internal events. These events can be cognitive or biological or physical (e.g. the intention to retrieve a memory, or some neurotransmitter regulation, or some visual energy input, respectively). Within this system, our brains try to represent external information, and to generate certain actions or responses.
In a similar manner, in origami, each fold is like an imprint of an event that happens. The effect of folding, however, is limited by the thickness, elasticity, and size of the paper, as well as the force of the folding. Folding could be a sharp strong crease, a light depression, or a curve. Folding also occurs along specific lines or regions on the paper at a time. Finally, folding has temporal order. Through a combination of these factors, the paper encodes what forces have been exerted on it, and represents all of that in a particular physical form. The end state.
The end state maybe be a meaningful shape, or it may have a meaningful function. We can transform a simple piece of paper into a form of a crane, or a box, or a really complex shape (origami experts have been able to do wonders!). We can even use the tension inherent in the folded paper as a spring with tremendous kinetic energy when released. We can also use folding to allow a large piece of material that ordinarily would not fit in specific area to conform to the shape and therefore fit in the area.
Likewise, the brain performs an interesting function in incorporating sensory information from the physical world and representing all the rich material within a single piece of organic tissue. This "folding" of information from one state to another may be a framework to understand neural function.
Consider that we can quantify the physical forces and characteristics of a piece of paper and its folds. Based on low level parameters, we can then determine what the origami will look like, what it can do, what properties its resulting form maintains. Applying a similar method to parameterize neural function may allow us to better describe how the properties of the brain relate to cognition and behavior. For example, the ease with which a paper folds may be dependent on the thickness of the paper (for a given material elasticity/rigidity/brittleness). This will in turn determine how much force must be applied to the paper to achieve a fold of a certain angle. In the same way, one property of the brain may be how strong the connections in a certain neuronal region may be. The stronger the connections, the easier it may be for a signal in one region to affect the activity in another. Another case in point, the brain maintains a certain level to generate new neurons in key parts of the cortex. Neurogenesis is known to occur even in late adulthood in the hippocampus and the peri-ventricular walls. Importantly, recent studies have shown that neurogenesis may be helpful in overcoming drug addiction. A possible mechanism might be that the new neurons enable the brain to represent existing addiction behaviors (information "folding"), in a new way that discourages addiction [link to relevant post]. Moreover, it is possible that different individuals have different rates, or ability, of neurogenesis, and external events or neurochemical interventions may also encourage neurogenesis. It is this rate of neurogenesis that might be a candidate parameter that determines how much a particular brain can fold.
Of course, this is all analogical. There is no necessary association between paper and brain. But, this presents an interesting way to approach the problem of quantifying brain function. Paper folding has been applied to several interesting real life problems. For example, the folding of solar-energy panels into a satellite so that large plates fit into a small structure for launching, and unfold in space to achieve maximum surface area for efficient energy collection. In addition, protein folding occurs according to the electro-chemical forces at the molecular level. Paper folding has been applied to understanding and even manipulating these forces to make protein molecules that achieve specific helpful biomolecular functions. Here's an example of applying origami to practical problem from an MIT group [link].
After all, the reason why origami is meaningful, is because we perceive cranes in a few simple folds.
Saturday, February 27, 2010
The Automation of Science
[REPORTS] The Automation of Science
"A robot scientist discovers orphan enzymes that take part in yeast metabolism."
This was published a while ago. But it may be worth mentioning because it could be the pivotal moment in AI.
Increasing neurogenesis might prevent drug addiction and relapse
Increasing neurogenesis might prevent drug addiction and relapse
"Researchers hope they have begun paving a new pathway in the fight against drug dependence.
This makes computational sense. Adding new neurons creates the possibility of forming new inhibitory connections, as well as de-potentiating the strength, or contribution, of existing ones. Such predifferentiated neurons serve as fresh unwritten computational space for which new behaviors and cognitions can be learned. In addition, old pathways which have been entrained and which are hard to change (because of prolonged experience or intensity) can have their effects counterbalanced.
Saturday, January 16, 2010
Friday, January 01, 2010
New Year Thoughts
"No one has seen God at any time. If we love one another, God abides in us, and His love has been perfected in us. By this we know that we abide in Him, and He in us, because He has given us of His Spirit. And we have seen and testify that the Father has sent the Son as Savior of the world. Whoever confesses that Jesus is the Son of God, God abides in him, and he in God. And we have known and believed the love that God has for us. God is love, and he who abides in love abides in God, and God in him.
"Love has been perfected among us in this: that we may have boldness in the day of judgment; because as He is, so are we in this world. There is no fear in love; but perfect love casts out fear, because fear involves torment. But he who fears has not been made perfect in love. We love Him because He first loved us.
"If someone says, "I love God," and hates his brother, he is a liar; for he who does not love his brother whom he has seen, how can he love God whom he has not seen? And this commandment we have from Him: that he who loves God must love his brother also."
1 John 4:7-21
How difficult it is to love! How easy it is to know we have to do it, to say it. But it is next to impossible to do it. John gives a good reminder that inspires and defines for us what life we should be living. If we chase after anything, it should be love. For God is love. This is the contemplation on the eve of 2009.
Merry Christmas and a Happy New Year.
Monday, December 07, 2009
Separation vs. Association
One way to evaluate what a cortical region may be doing with respect to this separation/association dichotomy may be to determine the number of neurons at the first level relative to the second level.
If the ratio of neurons at the first relative to second level is large, then the function of the second level is probably to associate. This is a many-to-few limitation. So various permutations and combinations at the first level are funneled into the reduced dimensionality of the second level. Therefore, some combinations are subsumed.
If the ratio of neurons from first to second levels is small, then there is the potential for expansion. The problem becomes a few-to-many scenario. The same combination at the first level may elicit several possible outcomes at the second level. There is information expansion.
...
Saturday, December 05, 2009
Slicing up HM's brain
Click here for live link. At the time of this posting, they are already at the occipital structures. So they may finish soon. Not sure what will happen to the link or the video once this entire process is done.
HM was a famous epileptic patient who had much of his medial temporal structures removed as a treatment for the epilepsy. The result of this operation rendered HM unable to form new long-term memories. This finding was instrumental in the notion that the medial temporal structures, such as the hippocampus, is important for memory. Since his operation, HM has been heavily studied. HM passed away on the 8 Dec 2008 due to respiratory failure. [More about HM]
Sunday, November 29, 2009
PhD Degree
Tuesday, November 24, 2009
Boston 2009
In fact, Charlene and I are here for the Psychophysiological Society annual meeting. This is the 50th anniversary of the conference and there was much to celebrate. This was my first time to attend this conference, and I was a little unsure of what to expect. Of course, this is not a neuroscience conference, so I did not expect to see the usual crowd. But to my surprise, I actually met a lot of old friends here. A bunch of people from the cognitive aging group, some people from Singapore, some friends from Japan, and a lot of people from Illinois! It felt good that this conference was, to me, more about meeting people than it was explicitly about the posters and talks, although some of those were interesting.
Fortuitously, we also met an old Singaporean friend who brought us to an awesome place farther out from Boston (Chung Shin Yuan) for the best bowl of 牛肉面, 豆漿 and 油條 that I have had in a long time.
And now...back home! Yay!
Berlin 2009
The origins of this trip to Europe for me, began with quite a lot of trouble. Namely because at the time of thinking about going for this trip, I was caught up in writing my dissertation, flying about between labs, worrying about data, and the future, and about spending money, and going home. But things happened, and I thought that this would be worth it, with the pleasant company (of course that alone is enough!), the seeing of new places, and the partaking of glorious beer and sausages. Besides, some people reflected to me that Berlin is a donut of a place.
This was my first time to Berlin, and my first time to Europe, actually. And I have to say, it was more than worth it. The culture alone is enough to leave a novel thought in my head. And that is saying something! One is reminded of reality, and its depth, which brings a sense of peace. But, enough of such philosophical nonsense. Here's a sample of the most impressionable experiences.
We also managed to pass by the wall without taking a photo of it...so too bad. This is because the wall is really gone. Nuff said.
Berlin...Ich glauber sie haben mein beir, vergessen!
More photos [here]
Friday, October 09, 2009
Developments after...
The reason why I am posting this now, is because I have just returned from a series of inspirational events. Traveling north and south between Champaign and Dallas takes its toll at times. You get up early at 6am, clean up, and get on the 7.30am flight (2 hrs). Reach DFW. Get onto the shuttle for the rental car mall of the airport (takes 15min). Get the car, drive to the Dallas lab (20min). Work. Check-in to Embassy Suites (which is an awesome hotel!). And on trips back, leave the lab by 4pm. Return the rental car, take the shuttle to terminal B of DFW. Pass security. Have a beer and a burger at TGIF in the airport before getting on the 6.50pm flight back to Champaign, and be picked up by a familiar face.
Do this 20 times.
Recently though, work has been progressing. Papers are being submitted. Finally. And hopefully accepted! But I think the most inspiring event happened yesterday. Instead of going south, I headed north and gave talks at Northwestern. The data seems well received and everyone seems so interested and in agreement. I felt glad. It was worthwhile to drive up 3hrs and back 3hrs for that one day of wonderful meetings and interactions.
Now, the main concern are next steps. Where to go after this one year of post-doctoral research? Another post-doctoral position? Faculty? Tough decisions with too many factors that plague my mind, that give no clear direction. No amount of grad school prepares you for this! For life!
One can only dive in.
Saturday, August 29, 2009
PhD
No one knows it all. But the defense is about stating what you know, and what you know you don't know. It is about being honest, and seeking truth. If what you find is real, it will bear itself. If what you think is true, you will find it. Sound familiar?
After the defense, we all went to Jim Gould's to have dinner. And it was, how shall I put it, fun! I think I felt it, that warmth of accomplishment. So that food tastes better. Sweetness has a fragrance, salt floods with depth, sour comes with juiciness, and bitter? There is no bitter.
Soon after, we watched an amazing movie - Inglorious Basterds! What a choice right? Brad Pitt was brilliant. Incidentally, Brangelina was in my defense.
The next day, I cleaned up the mess that was my apartment. It felt good to exert mindless sweat. The day after, we watched Mamma Mia. Tomorrow, BBQ!
That's what PhD is about, what happens before and after.
Tuesday, August 18, 2009
On the road to Permanent Head Damage
Now, its just one more powerpoint to go, and then...the same-o same-o. I sure hope all this is worth it! So far, it seems to be. If not for anything then just because life becomes a little clearer as we find out a little more, each step.
I like Douglas Adam's thought: Someone somewhere theorized that the minute a human being sits down and figures out how the universe works, it would immediately be replaced by another more complex universe...some say that this has already happened. Really, what I think about all this is that everything is like a donut. Nuff said.
Thursday, July 16, 2009
Agnostic Brain, Biased Mind - what does the FFA do?

Monday, July 13, 2009
Wicked Witch of the West steps on Scarecrow Brains with Magic Red Shoes
Thursday, July 09, 2009
3T Trio finds a new home in Beckman Institute

Sunday, June 21, 2009
An evening at Harvest Moon Drive-In

Friday, May 15, 2009
Cognitive abilities in kindergartners and first graders: A comparison, evaluation, and extension of models using data from Robinson et al. (1996)
It is known that very young children show less differentiated cognitive abilities. Children who perform well in tests such as those involving math, tend to have correlated performance in other tests such as in verbal tests. As children age and progress towards adolescence, however, their cognitive abilities becomes differentiated so that abilities such as math and verbal abilities are not necessarily equally developed in the child.
Presumably, this occurs because when children are very young, they are untrained and unaffected by external factors such as education and related experiences (e.g. streaming into majors). Thus, the best predictor of the child's performance is the individual difference or a general factor. With age, the child undergoes specialization where children start to develop more specific knowledge in selective domains. Some children become more trained at math, while others at language. Importantly, these abilities aren't always equally developed. This may be the underlying reason for differentiated abilities in older children.
This current paper is a methodological exploration of the data in Robinson et al. (1996) using various modifications of the basic structural equation model. The main results are consistent with differentiated abilities in first graders relative to kindergartners. Some discrepancies in Robinson et al.'s (1996) paper are noted as well.
[Download pdf of paper]
Tuesday, May 12, 2009
VSS Conference Day 4: My Poster

In this study, however, I postulated that under certain circumstances, the brain requires more neuronal recruitment in order to effectively process information for task demands. That is, repetition suppression becomes inefficient because it reduces the degrees of freedom that the brain can use to manipulate existing representations.
The study evaluated brain response in the fusiform region to face-pairs morphed at different levels of similarity. The idea is that the more similar face-pairs are, the more repetition suppression should be observed in the fusiform face area. Participants viewed the face-pairs under two different task instructions. The first task made face-pair similarity irrelevant. In this task, repetition suppression was observed to repeated faces. In the second task, face-pairs were made critical as participants had to make same-different judgments about the pairs. In this task, repetition suppression was eliminated.
The idea here is that in the same-different judgment task, the brain has to represent faces as distinctinctively as possible so that subtle morph differences can be detected. Thus, repetition suppression is prevented, possibly from executive function areas that process task instruction and exert a top-down modulatory control in the fusiform area.
The study also shows that there are individual differences in participants ability to exert this top-down modulation to regulate repetition suppression in the fusiform regions. This study was also performed in older adults, which will be reported in a subsequent research article. Briefly though, it is thought that older adults show declines in behavioral performance because of less distinctiveness in cognitive representations. This design is thus useful as a means to measure and related distinctinveness of representations in the brain and how that affects behavior.
Monday, May 11, 2009
VSS Conference Day 3: Illusion Night
Sunday, May 10, 2009
Saturday, May 09, 2009
VSS Conference Day 1: Arriving at Fort Myers Airport
Thursday, May 07, 2009
Default Network, Meditation, and Focus Training
It is then not hard to see the link between DN activity regulation and meditation. Meditation is an act of self-regulation of thoughts, and has been related to several positive outcomes, in terms of physical and mental health and ability. If we apply to adolescence and aging, perhaps one form of training that would be extremely deterministic of cognitive efficacy in older adults is the amount of focus training experienced.
Likewise, if we were to train indivduals on how to focus their mental thoughts, and improve them over time, might brain activity be modulated? And subsequently, might cognitive abilities be improved or preserved better with age?
Wednesday, May 06, 2009
A structural model of aging, brain and behavior

Monday, April 20, 2009
Saltimbocca Chicken
Simple Creamy Pasta
Ingredients
Pasta (spaghetti, or any other type, string noodles are probably best)
Mascapone cheese
Two eggs
Salt & pepper
Any kind of suitable additional ingredients (we used mushrooms and asparagus here)
Instructions
Cook spaghetti in salted boiling water. Prepare sauce in the meantime. Use two egg yolks in a bowl, add two and half large "scoops" of mascapone cheese, stir until a smooth sauce, add salt and pepper to taste. Once spaghetti is done, mix into sauce, add chopped mushrooms and fresh asparagus, mix again, and done!
Saltimbocca Chicken
Ingredients
4 chicken breasts (thin fillet)
4 proscuitto (or ham) same size as chicken, or cut to same size
1 lemon
Parsley
Sage leaves
1/2 cup flour
Salt & pepper
1 1/2 cup white wine
4 table spoon butter.
Instructions
Preheat oven to 200F (this is for keeping the cooked chicken warm later when preparing the sauce). Make sure chicken and ham are dry. Add some pepper into flour. Coat the chicken with light layer of the flour. Sprinkle some chopped sage onto chicken. Place ham on chicken. Heat 2 tablespoon olive oil in pan. Fry some large sage leaves, few seconds each side, then set aside on oil draining paper for later garnishing. Place chicken in oil, ham side down. Leave for 4-5min. Turn chicken, cook for another 3-4min. Remove chicken and place in oven. Drain oil from pan, but leave the bits from cooking the chicken. Pour the white wine into hot pan and scrape the bits into the wine, let the wine reduce to 1/3 cup. Add half lemon juice, chopped parsley, and butter, stir mixture into a nice sauce. Take chicken out of oven, place on plate, put fried sage leaves on top, and pour sauce over and serve. Done!
Sunday, April 19, 2009
Admiring a Predecessor's Work
Friday, April 17, 2009
Studying Adolescents
Thursday, April 16, 2009
My View on the Singapore River...Apparently!

Ha ha, forgot that I did this for Elaine long long time ago. Wow! Check out my interview.
Friday, April 10, 2009
15th July 2009 | |
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Beckman Institute 405 N. Mathews Ave Urbana, IL 61801 USA |
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Thursday, April 09, 2009
Tax Form 2009
