Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood: "Publication year: 2011
Source: Neurobiology of Aging, In Press, Corrected Proof, Available online 16 April 2011
Martin, Lövdén , Sabine, Schaefer , Hannes, Noack , Nils Christian, Bodammer , Simone, Kühn , ...
It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed..."
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