Slicing up HM's brain

Watch HM's brain being documented, slice by slice.

Click here for live link. At the time of this posting, they are already at the occipital structures. So they may finish soon. Not sure what will happen to the link or the video once this entire process is done.

HM was a famous epileptic patient who had much of his medial temporal structures removed as a treatment for the epilepsy. The result of this operation rendered HM unable to form new long-term memories. This finding was instrumental in the notion that the medial temporal structures, such as the hippocampus, is important for memory. Since his operation, HM has been heavily studied. HM passed away on the 8 Dec 2008 due to respiratory failure. [More about HM]

PhD Degree

Got my degree today in the mail. This has got to be the hardest sheet of paper to obtain in your lifetime!

Boston 2009

This is my first time to Boston, the beginning of America. The brief history is that the revolution of early settlers began here against the British colonialist at the time. It was a bunch of people living in Boston Commons, who held radical views of freedom, that banded together and stood up to the military authorities at the time. Today, Boston is full of history...and oysters.

In fact, Charlene and I are here for the Psychophysiological Society annual meeting. This is the 50th anniversary of the conference and there was much to celebrate. This was my first time to attend this conference, and I was a little unsure of what to expect. Of course, this is not a neuroscience conference, so I did not expect to see the usual crowd. But to my surprise, I actually met a lot of old friends here. A bunch of people from the cognitive aging group, some people from Singapore, some friends from Japan, and a lot of people from Illinois! It felt good that this conference was, to me, more about meeting people than it was explicitly about the posters and talks, although some of those were interesting.

Back to the oysters. Have I ever told you that Boston oysters (which are actually mostly from Maine or at least, further out at sea and are so technically not from Boston), are awesome? You can taste the sea in them. Basically, you should eat these raw. Don't even bother with the lemon, and don't drown yourself in oysters. Have a few, like 3 or 4. And stop. And let the ocean water that was sucked up by the oysters cleanse your body as it permeates your mouth. Seriously, that's really what its like.

Fortuitously, we also met an old Singaporean friend who brought us to an awesome place farther out from Boston (Chung Shin Yuan) for the best bowl of 牛肉面, 豆漿 and 油條 that I have had in a long time.

And now...back home! Yay!

Developments after...

This has got to be the wettest year ever. The rains got so bad this year that snow aphids snowed down on our small little town of Champaign. Winter rears its cold face around the corner now.

The reason why I am posting this now, is because I have just returned from a series of inspirational events. Traveling north and south between Champaign and Dallas takes its toll at times. You get up early at 6am, clean up, and get on the 7.30am flight (2 hrs). Reach DFW. Get onto the shuttle for the rental car mall of the airport (takes 15min). Get the car, drive to the Dallas lab (20min). Work. Check-in to Embassy Suites (which is an awesome hotel!). And on trips back, leave the lab by 4pm. Return the rental car, take the shuttle to terminal B of DFW. Pass security. Have a beer and a burger at TGIF in the airport before getting on the 6.50pm flight back to Champaign, and be picked up by a familiar face.

Do this 20 times.

Recently though, work has been progressing. Papers are being submitted. Finally. And hopefully accepted! But I think the most inspiring event happened yesterday. Instead of going south, I headed north and gave talks at Northwestern. The data seems well received and everyone seems so interested and in agreement. I felt glad. It was worthwhile to drive up 3hrs and back 3hrs for that one day of wonderful meetings and interactions.

Now, the main concern are next steps. Where to go after this one year of post-doctoral research? Another post-doctoral position? Faculty? Tough decisions with too many factors that plague my mind, that give no clear direction. No amount of grad school prepares you for this! For life!

One can only dive in.

PhD

Well, it is the start of the first weekend after defending. How was the defense? It was utterly fun. How often can you squash 5 brilliant minds in one room and have them talk about your work? How often can you debate with them and have them listen to your thoughts on things? How often can you hear them agree or even disagree with you in the most honest sense of it all? I would wish this on anybody who dares to try.

No one knows it all. But the defense is about stating what you know, and what you know you don't know. It is about being honest, and seeking truth. If what you find is real, it will bear itself. If what you think is true, you will find it. Sound familiar?

After the defense, we all went to Jim Gould's to have dinner. And it was, how shall I put it, fun! I think I felt it, that warmth of accomplishment. So that food tastes better. Sweetness has a fragrance, salt floods with depth, sour comes with juiciness, and bitter? There is no bitter.

Soon after, we watched an amazing movie - Inglorious Basterds! What a choice right? Brad Pitt was brilliant. Incidentally, Brangelina was in my defense.

The next day, I cleaned up the mess that was my apartment. It felt good to exert mindless sweat. The day after, we watched Mamma Mia. Tomorrow, BBQ!

That's what PhD is about, what happens before and after.

VSS Conference Day 4: Demo Night Exhibit

VSS Conference Day 4: Demo Night Dinner

VSS Conference Day 4: Beach Day

VSS Conference Day 4: My Poster

This poster was presented at VSS Conference 2009 [link to VSS website], morning session [download poster pdf]. This study investigated the effect of task instructions on repetition suppression in the brain. Repetition suppression refers to the phenomenon that the brain response to repeated stimuli is usually reduced or attenuated. It is thought that such reduction in brain response reflects less neuronal recruitment, and hence, a more "efficient" way of processing the same information.
In this study, however, I postulated that under certain circumstances, the brain requires more neuronal recruitment in order to effectively process information for task demands. That is, repetition suppression becomes inefficient because it reduces the degrees of freedom that the brain can use to manipulate existing representations.

The study evaluated brain response in the fusiform region to face-pairs morphed at different levels of similarity. The idea is that the more similar face-pairs are, the more repetition suppression should be observed in the fusiform face area. Participants viewed the face-pairs under two different task instructions. The first task made face-pair similarity irrelevant. In this task, repetition suppression was observed to repeated faces. In the second task, face-pairs were made critical as participants had to make same-different judgments about the pairs. In this task, repetition suppression was eliminated.

The idea here is that in the same-different judgment task, the brain has to represent faces as distinctinctively as possible so that subtle morph differences can be detected. Thus, repetition suppression is prevented, possibly from executive function areas that process task instruction and exert a top-down modulatory control in the fusiform area.

The study also shows that there are individual differences in participants ability to exert this top-down modulation to regulate repetition suppression in the fusiform regions. This study was also performed in older adults, which will be reported in a subsequent research article. Briefly though, it is thought that older adults show declines in behavioral performance because of less distinctiveness in cognitive representations. This design is thus useful as a means to measure and related distinctinveness of representations in the brain and how that affects behavior.

VSS Conference Day 3: Illusion Night

Start of Illusion Night! This is an annual event where conference attendees submit their visual illusions for competition to see who's is the best. The top 10 are selected and show their exhibit here at Illusion Night. You can check out the illusions online [link]. The one that really wowed me was the curveball illusion, its the most dramatic one!

VSS Conference Day 3: Club car to beach

VSS Conference Day 2: Naples Grande

Touring the hotel lobby grounds.

VSS Conference Day 2: Poster session

Check out the poster session.

VSS Conference Day 1: Arriving at Fort Myers Airport

Just arrived at Fort Myer's airport, Florida. It is 80F and humid. Nice. The airport is about 30 min away from Naples. The shuttle will bring us there. More as we go along in the conference.

Tax Form 2009

I have submitted my tax form again this year. For the record, every year they ask me the same thing about how many times I've traveled in and out of the States in previous years, and I think...does that change every year? So this year I said I was in the States in 2004 from date A to date B, then in 2005 from date C to date D...etc. But next year should I say that in 2004 I was in the States from date E to date F? Basically, are they dumb?

Photos from winter trip 2008 - 2009

Finally manage to upload all the photos. This was the most awesome trip in the universe!

Tokyo, Kyoto, Osaka, Hakone, back to Tokyo again with Charlene and family. [other photos]

Taipei, and Changhua with Charlene and family. [other photos]

Staying with Atsunobu and his mum, then Yokohama. [other photos]

Visiting Sam in New York. [other photos]

Some people know what I really really want

I've been wanting one for ages...

Laksa Craving

My current craving is for laksa. The Singapore kind, that has coconut in the soup and chu mi fen (white noodles), harm (cockles), tau pok, and hard boiled egg. The last laksa I had was with Sam in New York, somewhere in Queens! It was authentic...and brought back a sensation of comfort, nostalgia, heat, satisfaction, pleasure, contentment, happiness, joy, peace, and the sense that this is all I need. Really one.

The problem with laksa is that it is impossible to make here from scratch. No laksa leaf here. So have to rely on Prima, or go to New York, or heck, go home!

Dinner

We had the bunch come over yesterday. This was the menu:

Steamed Whole Grass Carp
spring onions
ginger
white wine
salt
olive oil
grass carp
cilantro

Steamed Prawns
brandy
prawns

Curried Lamb
lamb
tumeric powder
cumin seeds
lemon
garlic

Vegetable Clay Pot
tofu
cauliflower
shiitake mushroom
carrots

Boiled Kai Lan
kai lan
oyster sauce
garlic

Lotus Root Soup
lotus root
pork ribs
squid
peanuts
red dates

No pictures leh.

SFN Conference in DC 2008

Went to the conference to give my talk. It was, in my opinion, okay only lah. But I guess it was fun to take a break from the regular schedule. I decided that I'm only ok with DC. Not my type of city, but tolerable. Too much political buzz around.

Pictures here: http://travelingjosh.shutterfly.com/2824